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MYO5A (Unconventional myosin-Va) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Hepatocellular carcinoma, Lung cancer and 1 more.
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyse ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport.
IntOGen calls it a driver in 4 cohorts (2 activating, 1 loss-of-function), covering Invasive Breast Carcinoma, Hepatocellular Carcinoma, Lung, Neuroblastoma.
In plain words · MYO5A (Unconventional myosin-Va) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Hepatocellular carcinoma, Lung cancer and 1 more.
MYO5A (Unconventional myosin-Va) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Hepatocellular carcinoma, Lung cancer and 1 more.
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyse ATP in the presence of actin, which is essential for its function as a motor protein.
No product in this corpus aims at MYO5A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1994. Earliest sequence paper UniProt cites for the protein: Engle L.J. et al, Genomics, 1994, "Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene". Source.
Sources: HGNC HGNC:7602 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y4I1 (protein name, function text, keywords and locations (REST API)); IntOGen MYO5A (driver in 4 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyse ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarisation process involved in dendrite formation. Locus 15q21.2 (HGNC).
Query for this target: (TITLE:"MYO5A" OR ABSTRACT:"MYO5A" OR TITLE:"myosin VA" OR ABSTRACT:"myosin VA" OR TITLE:"Unconventional myosin-Va" OR ABSTRACT:"Unconventional myosin-Va" OR TITLE:"MYO5" OR ABSTRACT:"MYO5" OR TITLE:"GS1" OR ABSTRACT:"GS1" OR TITLE:"MYR12" OR ABSTRACT:"MYR12") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYO5A, not a curated reading list.
Shares Neuroblastoma (paediatric), IntOGen, Breast cancer (all types).
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma, IntOGen.
Shares Neuroblastoma (paediatric), IntOGen, Lung cancer (all types).
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma, IntOGen.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma.
Shares Neuroblastoma (paediatric), IntOGen, Breast cancer (all types).