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PRDM2 (PR domain zinc finger protein 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Renal cell carcinoma, Neuroblastoma and 1 more.
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Hepatocellular Carcinoma, Neuroblastoma, Papillary Renal Cell Carcinoma.
In plain words · PRDM2 (PR domain zinc finger protein 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Renal cell carcinoma, Neuroblastoma and 1 more.
PRDM2 (PR domain zinc finger protein 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Renal cell carcinoma, Neuroblastoma and 1 more.
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor.
No product in this corpus aims at PRDM2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Buyse I.M. et al, Proc. Natl. Acad. Sci. U.S.A, 1995, "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Source.
Sources: HGNC HGNC:9347 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13029 (protein name, function text, keywords and locations (REST API)); IntOGen PRDM2 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Location: Nucleus (UniProt). Locus 1p36.21 (HGNC).
Query for this target: (TITLE:"PRDM2" OR ABSTRACT:"PRDM2" OR TITLE:"PR/SET domain 2" OR ABSTRACT:"PR/SET domain 2" OR TITLE:"PR domain zinc finger protein 2" OR ABSTRACT:"PR domain zinc finger protein 2" OR TITLE:"RIZ1" OR ABSTRACT:"RIZ1" OR TITLE:"RIZ2" OR ABSTRACT:"RIZ2" OR TITLE:"KMT8" OR ABSTRACT:"KMT8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRDM2, not a curated reading list.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, Hepatocellular carcinoma, IntOGen.
Shares Neuroblastoma (paediatric), Hepatocellular carcinoma, IntOGen.
Shares Papillary renal cell carcinoma, Renal cell carcinoma.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, IntOGen.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, IntOGen.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, IntOGen.