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PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.21, somatic mutation 0.77). IntOGen calls it a driver in 9 cohorts (5 activating, 4 loss-of-function), covering Burkitt Lymphoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Malignant Lymphoma, Papillary Renal Cell Carcinoma.
In plain words · PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.
PCBP1 (Poly(rC)-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 2 more.
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing.
No product in this corpus aims at PCBP1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA PCBP1: RNA low tissue specificity; high antibody staining in 23 normal tissues; highest cancer staining colorectal cancer (10 of 12 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Lymphoma, Renal cell carcinoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (colorectal adenocarcinoma). (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q15365; CIViC gene PCBP1; IntOGen PCBP1; Human Protein Atlas PCBP1 tissue; Open Targets ENSG00000169564 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Aasheim H.-C. et al, Nucleic Acids Res, 1994, "Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K". Source.
Sources: HGNC HGNC:8647 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15365 (protein name, function text, keywords and locations (REST API)); CIViC gene PCBP1 (1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000169564 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0)); IntOGen PCBP1 (driver in 9 cohorts (Act 5, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing. Location: Nucleus; Cytoplasm (UniProt). Locus 2p13.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Bone marrow, Bronchus, Cervix, Epididymis, Fallopian tube, Heart muscle, Hippocampus.
Medium only: carcinoid, glioma, head and neck cancer, prostate cancer.
HPA PCBP1 tissue · HPA PCBP1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PCBP1" OR ABSTRACT:"PCBP1" OR TITLE:"poly rC binding protein 1" OR ABSTRACT:"poly rC binding protein 1" OR TITLE:"Poly rC -binding protein 1" OR ABSTRACT:"Poly rC -binding protein 1" OR TITLE:"HNRPE1" OR ABSTRACT:"HNRPE1" OR TITLE:"hnRNP-E1" OR ABSTRACT:"hnRNP-E1" OR TITLE:"HNRPX" OR ABSTRACT:"HNRPX") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCBP1, not a curated reading list.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, CIViC, IntOGen.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, CIViC, IntOGen.
Shares Papillary renal cell carcinoma, Renal cell carcinoma, CIViC, IntOGen.
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Papillary renal cell carcinoma, Renal cell carcinoma, IntOGen, Non-Hodgkin lymphoma (all types).