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TFAP4 (Transcription factor AP-4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Burkitt lymphoma.
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Burkitt Lymphoma, Non-Hodgkin Lymphoma.
In plain words · TFAP4 (Transcription factor AP-4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Burkitt lymphoma.
TFAP4 (Transcription factor AP-4) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Burkitt lymphoma.
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Location: Nucleus (UniProt).
No product in this corpus aims at TFAP4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA TFAP4: RNA low tissue specificity; high antibody staining in 5 normal tissues; highest cancer staining colorectal cancer (7 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q01664; CIViC gene TFAP4; IntOGen TFAP4; Human Protein Atlas TFAP4 tissue; Open Targets ENSG00000090447 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Hu Y.-F. et al, Genes Dev, 1990, "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity". Source.
Sources: HGNC HGNC:11745 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01664 (protein name, function text, keywords and locations (REST API)); CIViC gene TFAP4 (1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)); IntOGen TFAP4 (driver in 3 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Location: Nucleus (UniProt). Locus 16p13.3 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
Medium: Appendix, Bone marrow, Breast, Bronchus, Cerebellum, Cerebral cortex, Duodenum, Endometrium.
Medium only: carcinoid, cervical cancer, glioma, liver cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TFAP4" OR ABSTRACT:"TFAP4" OR TITLE:"transcription factor AP-4" OR ABSTRACT:"transcription factor AP-4" OR TITLE:"Transcription factor AP-4" OR ABSTRACT:"Transcription factor AP-4" OR TITLE:"AP-4" OR ABSTRACT:"AP-4" OR TITLE:"bHLHc41" OR ABSTRACT:"bHLHc41") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TFAP4, not a curated reading list.
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.