Loading
BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.
UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A".
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Plasma Cell Myeloma.
In plain words · BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.
BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.
UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A". Locus 12q24.31 (HGNC).
No product in this corpus aims at BCL7A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA BCL7A: RNA low tissue specificity; blood lineage group enriched (B-cells 2 nTPM, dendritic cells 3 nTPM); high antibody staining in 2 normal tissues; highest cancer staining glioma (4 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q4VC05; CIViC gene BCL7A; IntOGen BCL7A; Human Protein Atlas BCL7A tissue; Open Targets ENSG00000110987 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Zani V.J. et al, Blood, 1996, "Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon". Source.
Sources: HGNC HGNC:1004 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q4VC05 (protein name, function text, keywords and locations (REST API)); CIViC gene BCL7A (2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)); IntOGen BCL7A (driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A". Locus 12q24.31 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: group enriched (B-cells 2 nTPM, dendritic cells 3 nTPM).
Medium: Appendix, Breast, Bronchus, Caudate, Cerebellum, Cerebral cortex, Endometrium, Epididymis.
Medium only: breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"BCL7A" OR ABSTRACT:"BCL7A" OR TITLE:"BAF chromatin remodeling complex subunit BCL7A" OR ABSTRACT:"BAF chromatin remodeling complex subunit BCL7A" OR TITLE:"B-cell CLL/lymphoma 7 protein family member A" OR ABSTRACT:"B-cell CLL/lymphoma 7 protein family member A" OR TITLE:"SMARCJ1" OR ABSTRACT:"SMARCJ1" OR TITLE:"BCL7" OR ABSTRACT:"BCL7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCL7A, not a curated reading list.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Multiple myeloma.
Shares Burkitt lymphoma, Diffuse large B-cell lymphoma, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.