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FOXO1 (Forkhead box protein O1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Non-Hodgkin lymphoma, Ovarian cancer and 4 more.
Transcription factor that is the main target of insulin signalling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.26, literature 0.99, genetic association 0.38, somatic mutation 0.83). IntOGen calls it a driver in 6 cohorts (5 activating, 1 loss-of-function), covering Burkitt Lymphoma, Lung Squamous Cell Carcinoma, Malignant Lymphoma, Non-Hodgkin Lymphoma.
In plain words · FOXO1 (Forkhead box protein O1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Non-Hodgkin lymphoma, Ovarian cancer and 4 more.
FOXO1 (Forkhead box protein O1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Non-Hodgkin lymphoma, Ovarian cancer and 4 more.
Transcription factor that is the main target of insulin signalling and regulates metabolic homeostasis in response to oxidative stress.
No product in this corpus aims at FOXO1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance) and a fusion partner (UniProt records a translocation), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA FOXO1: RNA tissue enhanced (skeletal muscle 84 nTPM); high antibody staining in 9 normal tissues; highest cancer staining lymphoma (7 of 12 high). Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST), Lymphoma, Ovarian cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q12778; CIViC gene FOXO1; IntOGen FOXO1; Human Protein Atlas FOXO1 tissue; Open Targets ENSG00000150907 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Galili et al, Nat. Genet, 1993, "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma". Source.
Sources: HGNC HGNC:3819 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q12778 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXO1 (2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000150907 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: ovarian cancer 0.50, sarcoma 0.65, non-Hodgkin lymphoma 0.58, rhabdomyosarcoma 0.62 (GraphQL API, CC0)); IntOGen FOXO1 (driver in 6 cohorts (Act 5, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor that is the main target of insulin signalling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Location: Cytoplasm; Nucleus (UniProt). Locus 13q14.11 (HGNC).
RNA: tissue enhanced (skeletal muscle 84 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Appendix, Bone marrow, Bronchus, Cervix, Colon, Esophagus.
Medium only: carcinoid, cervical cancer, colorectal cancer, ovarian cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOXO1" OR ABSTRACT:"FOXO1" OR TITLE:"forkhead box O1" OR ABSTRACT:"forkhead box O1" OR TITLE:"Forkhead box protein O1" OR ABSTRACT:"Forkhead box protein O1" OR TITLE:"FKH1" OR ABSTRACT:"FKH1" OR TITLE:"FOXO1A" OR ABSTRACT:"FOXO1A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXO1, not a curated reading list.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), CIViC, Open Targets Platform.