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MYOD1 (Myoblast determination protein 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Colorectal cancer and Rhabdomyosarcoma.
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts.
CIViC holds 11 clinical evidence items and 1 assertion across 1 variant. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.87, affected pathway 0.43, genetic association 0.35, somatic mutation 0.97).
In plain words · MYOD1 (Myoblast determination protein 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Colorectal cancer and Rhabdomyosarcoma.
MYOD1 (Myoblast determination protein 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Colorectal cancer and Rhabdomyosarcoma.
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
No product in this corpus aims at MYOD1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MYOD1: RNA tissue enriched (skeletal muscle 34 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Sarcomas (soft tissue, bone, GIST), Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas MYOD1 tissue; Open Targets ENSG00000129152 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Braun et al, EMBO J, 1989, "Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products". Source.
Sources: HGNC HGNC:7611 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15172 (protein name, function text, keywords and locations (REST API)); CIViC gene MYOD1 (11 evidence items, 1 assertions, 1 variants; diseases: Spindle Cell Rhabdomyosarcoma, Rhabdomyosarcoma (GraphQL API, CC0)); Open Targets ENSG00000129152 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.53, sarcoma 0.60, rhabdomyosarcoma 0.57 (GraphQL API, CC0))
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins. Location: Nucleus (UniProt). Locus 11p15.1 (HGNC).
RNA: tissue enriched (skeletal muscle 34 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Ovary Serous Cystadenocarcinoma 1 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MYOD1" OR ABSTRACT:"MYOD1" OR TITLE:"myogenic differentiation 1" OR ABSTRACT:"myogenic differentiation 1" OR TITLE:"Myoblast determination protein 1" OR ABSTRACT:"Myoblast determination protein 1" OR TITLE:"bHLHc1" OR ABSTRACT:"bHLHc1" OR TITLE:"MYF3" OR ABSTRACT:"MYF3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYOD1, not a curated reading list.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), CIViC, Open Targets Platform.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).