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PAX3 (Paired box protein Pax-3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10.
Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes genetic literature 0.61, affected pathway 0.40, literature 0.96, genetic association 0.75, somatic mutation 0.98, animal model 0.57).
In plain words · PAX3 (Paired box protein Pax-3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.
PAX3 (Paired box protein Pax-3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis.
No product in this corpus aims at PAX3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Burri et al, EMBO J, 1989, "Conservation of the paired domain in metazoans and its structure in three isolated human genes". Source.
Sources: HGNC HGNC:8617 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23760 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135903 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: sarcoma 0.77, rhabdomyosarcoma 0.74 (GraphQL API, CC0))
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10. Location: Nucleus (UniProt). Locus 2q36.1 (HGNC).
Query for this target: (TITLE:"PAX3" OR ABSTRACT:"PAX3" OR TITLE:"paired box 3" OR ABSTRACT:"paired box 3" OR TITLE:"Paired box protein Pax-3" OR ABSTRACT:"Paired box protein Pax-3" OR TITLE:"HUP2" OR ABSTRACT:"HUP2" OR TITLE:"PAX-3" OR ABSTRACT:"PAX-3" OR TITLE:"WS1" OR ABSTRACT:"WS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAX3, not a curated reading list.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Rhabdomyosarcoma, Sarcomas (soft tissue, bone, GIST).