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SIN3A (Paired amphipathic helix protein Sin3a) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Diffuse large B-cell lymphoma and Burkitt lymphoma.
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonise MYC oncogenic activities.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Burkitt Lymphoma, Non-Hodgkin Lymphoma.
In plain words · SIN3A (Paired amphipathic helix protein Sin3a) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Diffuse large B-cell lymphoma and Burkitt lymphoma.
SIN3A (Paired amphipathic helix protein Sin3a) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Diffuse large B-cell lymphoma and Burkitt lymphoma.
Acts as a transcriptional repressor. Corepressor for REST.
No product in this corpus aims at SIN3A yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA SIN3A: RNA low tissue specificity; high antibody staining in 3 normal tissues; highest cancer staining cervical cancer (2 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q96ST3; CIViC gene SIN3A; IntOGen SIN3A; Human Protein Atlas SIN3A tissue; Open Targets ENSG00000169375 associations
First described 2001. Earliest sequence paper UniProt cites for the protein: Guo J.H. et al, 2001. Source.
Sources: HGNC HGNC:19353 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96ST3 (protein name, function text, keywords and locations (REST API)); CIViC gene SIN3A (2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)); IntOGen SIN3A (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonise MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 15q24.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bronchus, Cerebellum, Cervix, Colon, Duodenum, Endometrium, Epididymis, Esophagus.
Medium only: breast cancer, colorectal cancer, endometrial cancer, glioma.
HPA SIN3A tissue · HPA SIN3A pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"SIN3A" OR ABSTRACT:"SIN3A" OR TITLE:"SIN3 transcription regulator family member A" OR ABSTRACT:"SIN3 transcription regulator family member A" OR TITLE:"Paired amphipathic helix protein Sin3a" OR ABSTRACT:"Paired amphipathic helix protein Sin3a" OR TITLE:"KIAA0700" OR ABSTRACT:"KIAA0700" OR TITLE:"DKFZP434K2235" OR ABSTRACT:"DKFZP434K2235") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIN3A, not a curated reading list.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, Diffuse large B-cell lymphoma, Non-Hodgkin lymphoma (all types).
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.
Shares Burkitt lymphoma, CIViC, IntOGen, Diffuse large B-cell lymphoma.