{"entity":{"id":"sin3a","kind":"target","name":"SIN3A","aka":["SIN3 transcription regulator family member A","Paired amphipathic helix protein Sin3a","KIAA0700","DKFZP434K2235"],"tldr":"SIN3A (Paired amphipathic helix protein Sin3a) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Diffuse large B-cell lymphoma and Burkitt lymphoma.","summary":"Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonise MYC oncogenic activities.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Burkitt Lymphoma, Non-Hodgkin Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19353","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19353"},{"label":"UniProt Q96ST3","url":"https://www.uniprot.org/uniprotkb/Q96ST3/entry"},{"label":"NCBI Gene 25942","url":"https://www.ncbi.nlm.nih.gov/gene/25942"},{"label":"Ensembl ENSG00000169375","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169375"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["non-hodgkin-lymphoma","dlbcl","burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SIN3A","role":["tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:19353","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19353","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96ST3","url":"https://www.uniprot.org/uniprotkb/Q96ST3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SIN3A","url":"https://civicdb.org/features/9957","note":"2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen SIN3A","url":"https://www.intogen.org/search?gene=SIN3A","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"one-type","specificityNote":"Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA SIN3A: RNA low tissue specificity; high antibody staining in 3 normal tissues; highest cancer staining cervical cancer (2 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q96ST3","url":"https://www.uniprot.org/uniprotkb/Q96ST3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SIN3A","url":"https://civicdb.org/features/9957","note":"2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen SIN3A","url":"https://www.intogen.org/search?gene=SIN3A","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas SIN3A tissue","url":"https://www.proteinatlas.org/ENSG00000169375-SIN3A/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000169375 associations","url":"https://platform.opentargets.org/target/ENSG00000169375/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:19353","ensembl":"ENSG00000169375","uniprot":"Q96ST3","entrez":"25942","firstDescribed":2001,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Guo J.H. et al, 2001.","firstDescribedSource":"https://www.uniprot.org/uniprotkb/Q96ST3/entry","biology":"Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonise MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 15q24.2 (HGNC).","whereFound":["Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (NHL)","Diffuse large B-cell lymphoma: CIViC evidence names this disease","Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (BL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/sin3a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}