{"entity":{"id":"bcl7a","kind":"target","name":"BCL7A","aka":["BAF chromatin remodeling complex subunit BCL7A","B-cell CLL/lymphoma 7 protein family member A","SMARCJ1","BCL7"],"tldr":"BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.","summary":"UniProt has no function text for Q4VC05; HGNC names it \"BAF chromatin remodeling complex subunit BCL7A\".\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1004","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1004"},{"label":"UniProt Q4VC05","url":"https://www.uniprot.org/uniprotkb/Q4VC05/entry"},{"label":"NCBI Gene 605","url":"https://www.ncbi.nlm.nih.gov/gene/605"},{"label":"Ensembl ENSG00000110987","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110987"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["non-hodgkin-lymphoma","multiple-myeloma","dlbcl","burkitt-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 2 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"BCL7A","role":["oncogene-driver","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:1004","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1004","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q4VC05","url":"https://www.uniprot.org/uniprotkb/Q4VC05/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BCL7A","url":"https://civicdb.org/features/567","note":"2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen BCL7A","url":"https://www.intogen.org/search?gene=BCL7A","note":"driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA BCL7A: RNA low tissue specificity; blood lineage group enriched (B-cells 2 nTPM, dendritic cells 3 nTPM); high antibody staining in 2 normal tissues; highest cancer staining glioma (4 of 11 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q4VC05","url":"https://www.uniprot.org/uniprotkb/Q4VC05/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene BCL7A","url":"https://civicdb.org/features/567","note":"2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen BCL7A","url":"https://www.intogen.org/search?gene=BCL7A","note":"driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas BCL7A tissue","url":"https://www.proteinatlas.org/ENSG00000110987-BCL7A/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000110987 associations","url":"https://platform.opentargets.org/target/ENSG00000110987/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:1004","ensembl":"ENSG00000110987","uniprot":"Q4VC05","entrez":"605","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Zani V.J. et al, Blood, 1996, \"Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8605326/","biology":"UniProt has no function text for Q4VC05; HGNC names it \"BAF chromatin remodeling complex subunit BCL7A\". Locus 12q24.31 (HGNC).","whereFound":["Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Diffuse large B-cell lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (DLBCLNOS)","Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (BL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/bcl7a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}