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EIF4A1 (Eukaryotic initiation factor 4A-I) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · EIF4A1 (Eukaryotic initiation factor 4A-I) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.
EIF4A1 (Eukaryotic initiation factor 4A-I) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.
No product in this corpus aims at EIF4A1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists EIF4A1 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA EIF4A1: RNA low tissue specificity; no normal tissue stained high; highest cancer staining testis cancer (3 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas EIF4A1 tissue; Open Targets ENSG00000161960 associations
First described 1993. Earliest sequence paper UniProt cites for the protein: Kim N.-S. et al, Nucleic Acids Res, 1993, "Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI". Source.
Sources: HGNC HGNC:3282 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P60842 (protein name, function text, keywords and locations (REST API)); CIViC gene EIF4A1 (1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0))
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth. Location: Cytoplasm, perinuclear region; Cell membrane; Cytoplasm, Stress granule (UniProt). Locus 17p13.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: breast cancer, cervical cancer, endometrial cancer, glioma.
HPA EIF4A1 tissue · HPA EIF4A1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EIF4A1" OR ABSTRACT:"EIF4A1" OR TITLE:"eukaryotic translation initiation factor 4A1" OR ABSTRACT:"eukaryotic translation initiation factor 4A1" OR TITLE:"Eukaryotic initiation factor 4A-I" OR ABSTRACT:"Eukaryotic initiation factor 4A-I" OR TITLE:"DDX2A" OR ABSTRACT:"DDX2A" OR TITLE:"EIF-4A" OR ABSTRACT:"EIF-4A" OR TITLE:"EIF4A" OR ABSTRACT:"EIF4A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EIF4A1, not a curated reading list.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.