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BMP7 (Bone morphogenetic protein 7) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · BMP7 (Bone morphogenetic protein 7) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.
BMP7 (Bone morphogenetic protein 7) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Burkitt lymphoma.
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis.
No product in this corpus aims at BMP7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA BMP7: RNA tissue enhanced (choroid plexus 34 nTPM, thyroid gland 43 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas BMP7 tissue; Open Targets ENSG00000101144 associations
First described 1990. Earliest sequence paper UniProt cites for the protein: Oezkaynak et al, EMBO J, 1990, "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family". Source.
Sources: HGNC HGNC:1074 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18075 (protein name, function text, keywords and locations (REST API)); CIViC gene BMP7 (1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0))
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, haematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signalling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signalling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Location: Secreted (UniProt). Locus 20q13.31 (HGNC).
RNA: tissue enhanced (choroid plexus 34 nTPM, thyroid gland 43 nTPM), detected in many normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"BMP7" OR ABSTRACT:"BMP7" OR TITLE:"bone morphogenetic protein 7" OR ABSTRACT:"bone morphogenetic protein 7" OR TITLE:"Bone morphogenetic protein 7" OR ABSTRACT:"Bone morphogenetic protein 7" OR TITLE:"OP-1" OR ABSTRACT:"OP-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BMP7, not a curated reading list.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.
Shares Burkitt lymphoma, CIViC.