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NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.28, somatic mutation 0.76). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Papillary Renal Cell Carcinoma, Small Intestinal Carcinoma.
In plain words · NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.
NUP214 (Nuclear pore complex protein Nup214) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Renal cell carcinoma and 4 more.
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport.
No product in this corpus aims at NUP214 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1992. Earliest sequence paper UniProt cites for the protein: Von Lindern et al, Mol. Cell. Biol, 1992, "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Source.
Sources: HGNC HGNC:8064 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35658 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126883 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.55, non-Hodgkin lymphoma 0.59, myeloproliferative neoplasm 0.53, leukaemia 0.60 (GraphQL API, CC0)); IntOGen NUP214 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. Location: Nucleus, nuclear pore complex (UniProt). Locus 9q34.13 (HGNC).
Query for this target: (TITLE:"NUP214" OR ABSTRACT:"NUP214" OR TITLE:"nucleoporin 214" OR ABSTRACT:"nucleoporin 214" OR TITLE:"Nuclear pore complex protein Nup214" OR ABSTRACT:"Nuclear pore complex protein Nup214" OR TITLE:"D9S46E" OR ABSTRACT:"D9S46E" OR TITLE:"N214" OR ABSTRACT:"N214") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUP214, not a curated reading list.
Shares Papillary renal cell carcinoma, Leukaemia (all types), Renal cell carcinoma, Acute lymphoblastic leukaemia.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Renal cell carcinoma, Acute lymphoblastic leukaemia.
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types).
Shares Myeloproliferative neoplasms (PV, ET, myelofibrosis), Leukaemia (all types), Acute lymphoblastic leukaemia, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, IntOGen, Non-Hodgkin lymphoma (all types).