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MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.52, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.
In plain words · MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.
MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
No product in this corpus aims at MSI2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:18585 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96DH6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000153944 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: skin cancer 0.50, breast cancer 0.56 (GraphQL API, CC0)); IntOGen MSI2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Location: Cytoplasm (UniProt). Locus 17q22 (HGNC).
Query for this target: (TITLE:"MSI2" OR ABSTRACT:"MSI2" OR TITLE:"musashi RNA binding protein 2" OR ABSTRACT:"musashi RNA binding protein 2" OR TITLE:"RNA-binding protein Musashi homolog 2" OR ABSTRACT:"RNA-binding protein Musashi homolog 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MSI2, not a curated reading list.
Shares Neuroblastoma (paediatric), Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Neuroblastoma (paediatric), IntOGen, Breast cancer (all types).
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), Skin cancer (all types), Open Targets Platform.
Shares Neuroblastoma (paediatric), IntOGen, Open Targets Platform.
Shares Neuroblastoma (paediatric), IntOGen.
Shares Neuroblastoma (paediatric), IntOGen.