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Galectin-9 is a sugar-binding protein that presses TIM-3 on T cells and can kill the helper T cells that carry it. Tumour blood vessels make more of it than normal ones.
LGALS9 (chromosome 17q11.2) encodes galectin-9, a galactoside-binding lectin that is the ligand for HAVCR2 (TIM-3); binding induces death of T-helper type 1 lymphocytes. It is expressed in peripheral blood leukocytes and lymphatic tissues and in lung, liver, breast and kidney, with higher levels in tumour endothelial cells than normal endothelium at the protein level (UniProt O00182).
In plain words · Galectin-9 is a sugar-binding protein that presses TIM-3 on T cells and can kill the helper T cells that carry it. Tumour blood vessels make more of it than normal ones.
Galectin-9 is a sugar-binding protein that presses TIM-3 on T cells and can kill the helper T cells that carry it. Tumour blood vessels make more of it than normal ones.
A tandem-repeat galectin; one of two TIM-3 ligands in this map, with CEACAM1.
No product in this corpus aims at Galectin-9 (LGALS9) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1997. Earliest sequence paper UniProt cites for the protein: Tuereci et al, J. Biol. Chem, 1997, "Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease". Source.
Sources: HGNC HGNC:6570 (approved symbol, name, aliases and cross-references); UniProt O00182 (protein name, function and tissue specificity)
A tandem-repeat galectin; one of two TIM-3 ligands in this map, with CEACAM1.
Query for this target: (TITLE:"Galectin-9" OR ABSTRACT:"Galectin-9" OR TITLE:"LGALS9" OR ABSTRACT:"LGALS9" OR TITLE:"galectin 9" OR ABSTRACT:"galectin 9" OR TITLE:"Gal-9" OR ABSTRACT:"Gal-9" OR TITLE:"LGALS9A" OR ABSTRACT:"LGALS9A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Galectin-9 (LGALS9), not a curated reading list.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.