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GITR is an accelerator on T cells that agonist antibodies tried to press to boost immunotherapy. Several reached early trials; one programme was dropped for reasons unrelated to safety.
TNFRSF18 (chromosome 1p36.33) encodes GITR, the receptor for TNFSF18 (GITR ligand), which seems to be involved in interactions between activated T lymphocytes and endothelial cells and in the regulation of T-cell-receptor-mediated cell death, and mediates NF-kappa-B activation through the TRAF2/NIK pathway; it is expressed in lymph node and peripheral blood leukocytes and weakly in spleen (UniProt Q9Y5U5). BMS-986156, a GITR agonist, completed phase 1/2 alone and with nivolumab (NCT02598960); TRX518 was discontinued for reasons unrelated to safety (NCT03861403).
In plain words · GITR is an accelerator on T cells that agonist antibodies tried to press to boost immunotherapy. Several reached early trials; one programme was dropped for reasons unrelated to safety.
GITR is an accelerator on T cells that agonist antibodies tried to press to boost immunotherapy. Several reached early trials; one programme was dropped for reasons unrelated to safety.
A TNF-receptor-superfamily costimulator on activated and regulatory T cells.
No product in this corpus aims at GITR (TNFRSF18) yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
First described 1999. Earliest sequence paper UniProt cites for the protein: Gurney A.L. et al, Curr. Biol, 1999, "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR". Source.
Sources: HGNC HGNC:11914 (approved symbol, name, aliases and cross-references); UniProt Q9Y5U5 (protein name, function and tissue specificity)
A TNF-receptor-superfamily costimulator on activated and regulatory T cells.
Query for this target: (TITLE:"GITR" OR ABSTRACT:"GITR" OR TITLE:"TNFRSF18" OR ABSTRACT:"TNFRSF18" OR TITLE:"AITR" OR ABSTRACT:"AITR" OR TITLE:"CD357" OR ABSTRACT:"CD357" OR TITLE:"TNF receptor superfamily member 18" OR ABSTRACT:"TNF receptor superfamily member 18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GITR (TNFRSF18), not a curated reading list.
Shares CD137 (4-1BB, TNFRSF9), Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.