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TDO2 does the same job as IDO1, breaking down tryptophan into kynurenine, which quietens T cells. It is one reason IDO1 inhibitors alone may not have been enough; no TDO2 drug has reached late trials.
TDO2 (chromosome 4q32.1) is a haem-dependent dioxygenase that catalyses the oxidative cleavage of the L-tryptophan pyrrole ring, converting it to N-formyl-L-kynurenine (UniProt P48775). IDO1 and TDO2 catalyse the commitment step of the kynurenine pathway; kynurenine activates the aryl hydrocarbon receptor, generating immune-tolerant dendritic cells and regulatory T cells and a tumour microenvironment defective at recognising cancer cells (Cheong and Sun 2018, Trends Pharmacol Sci). No TDO2-selective agent was found in ClinicalTrials.gov under the names the corpus knows.
In plain words · TDO2 does the same job as IDO1, breaking down tryptophan into kynurenine, which quietens T cells. It is one reason IDO1 inhibitors alone may not have been enough; no TDO2 drug has reached late trials.
TDO2 does the same job as IDO1, breaking down tryptophan into kynurenine, which quietens T cells. It is one reason IDO1 inhibitors alone may not have been enough; no TDO2 drug has reached late trials.
The liver-type tryptophan dioxygenase; UniProt records no tissue distribution for the human protein, so none is claimed here.
No product in this corpus aims at TDO2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Comings D.E. et al, Genomics, 1995, "Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat". Source.
Sources: HGNC HGNC:11708 (approved symbol, name, aliases and cross-references); UniProt P48775 (protein name, function and tissue specificity)
The liver-type tryptophan dioxygenase; UniProt records no tissue distribution for the human protein, so none is claimed here.
Query for this target: (TITLE:"TDO2" OR ABSTRACT:"TDO2" OR TITLE:"tryptophan 2,3-dioxygenase" OR ABSTRACT:"tryptophan 2,3-dioxygenase" OR TITLE:"TDO" OR ABSTRACT:"TDO") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TDO2, not a curated reading list.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.