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CD27 is an accelerator on most T cells that is pressed by CD70. Agonist antibodies against it reached phase 2 in lymphoma; its partner CD70 is a separate target for antibodies and CAR-T cells.
CD27 (chromosome 12p13.31) is a costimulatory immune-checkpoint receptor on T cells, NK cells and B cells that is activated by its ligand CD70 on B cells; CD70-CD27 signalling mediates antigen-specific T-cell activation and expansion (UniProt P26842). It is found in most T lymphocytes. Varlilumab (CDX-1127), a CD27 agonist antibody, reached phase 2 with nivolumab in relapsed aggressive B-cell lymphoma (NCT03038672); several combination studies were terminated for portfolio re-prioritisation (NCT02386111).
In plain words · CD27 is an accelerator on most T cells that is pressed by CD70. Agonist antibodies against it reached phase 2 in lymphoma; its partner CD70 is a separate target for antibodies and CAR-T cells.
CD27 is an accelerator on most T cells that is pressed by CD70. Agonist antibodies against it reached phase 2 in lymphoma; its partner CD70 is a separate target for antibodies and CAR-T cells.
A TNF-receptor-superfamily costimulator; the CD70 side has its own target page.
No product in this corpus aims at CD27 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
First described 1991. Earliest sequence paper UniProt cites for the protein: Camerini et al, J. Immunol, 1991, "The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family". Source.
Sources: HGNC HGNC:11922 (approved symbol, name, aliases and cross-references); UniProt P26842 (protein name, function and tissue specificity)
A TNF-receptor-superfamily costimulator; the CD70 side has its own target page.
Query for this target: (TITLE:"CD27" OR ABSTRACT:"CD27" OR TITLE:"TNFRSF7" OR ABSTRACT:"TNFRSF7" OR TITLE:"CD27 molecule" OR ABSTRACT:"CD27 molecule" OR TITLE:"Tp55" OR ABSTRACT:"Tp55" OR TITLE:"S152" OR ABSTRACT:"S152") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD27, not a curated reading list.
Shares CD137 (4-1BB, TNFRSF9), Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares CD137 (4-1BB, TNFRSF9), Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.