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CD39 is the first of two enzymes that turn the ATP spilt by dying tumour cells into adenosine, which sedates T cells. Blocking it keeps the ATP alarm ringing; one antibody has completed phase 2 in pancreatic cancer.
ENTPD1 (chromosome 10q24.1) catalyses the hydrolysis of nucleoside triphosphates and diphosphates, sequentially removing phosphate groups to leave nucleoside monophosphates; it is expressed primarily on activated lymphoid cells and in endothelium, and highly in placenta, lung, skeletal muscle and kidney (UniProt P49961). CD39 and CD73 together catabolise extracellular ATP into adenosine, and both, with adenosine receptors, have emerged as therapeutic targets (Allard et al. 2019, Immunol Rev). TTX-030, an anti-CD39 antibody, completed a phase 2 study with chemotherapy, with or without budigalimab, in first-line metastatic pancreatic cancer (NCT06119217).
In plain words · CD39 is the first of two enzymes that turn the ATP spilt by dying tumour cells into adenosine, which sedates T cells. Blocking it keeps the ATP alarm ringing; one antibody has completed phase 2 in pancreatic cancer.
CD39 is the first of two enzymes that turn the ATP spilt by dying tumour cells into adenosine, which sedates T cells. Blocking it keeps the ATP alarm ringing; one antibody has completed phase 2 in pancreatic cancer.
The upstream ectonucleotidase of the adenosine axis; CD73 (NT5E) finishes the conversion.
No product in this corpus aims at CD39 (ENTPD1) yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1994. Earliest sequence paper UniProt cites for the protein: Maliszewski C.R. et al, J. Immunol, 1994, "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization". Source.
Sources: HGNC HGNC:3363 (approved symbol, name, aliases and cross-references); UniProt P49961 (protein name, function and tissue specificity)
The upstream ectonucleotidase of the adenosine axis; CD73 (NT5E) finishes the conversion.
Query for this target: (TITLE:"CD39" OR ABSTRACT:"CD39" OR TITLE:"ENTPD1" OR ABSTRACT:"ENTPD1" OR TITLE:"NTPDase-1" OR ABSTRACT:"NTPDase-1" OR TITLE:"ectonucleoside triphosphate diphosphohydrolase 1" OR ABSTRACT:"ectonucleoside triphosphate diphosphohydrolase 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD39 (ENTPD1), not a curated reading list.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.