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CD86 is one of the two B7 molecules on antigen-presenting cells that either wake a T cell up (through CD28) or calm it down (through CTLA-4). Ipilimumab works by stopping CTLA-4 from hogging CD86 and CD80.
CD86 (chromosome 3q13.33) is a costimulatory molecule of the immunoglobulin superfamily on the surface of antigen-presenting cells that acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T cells by binding the constitutively expressed CD28 receptor (UniProt P42081). CTLA-4 binds CD80 and CD86 with considerably stronger affinity than CD28 does and acts as a decoy receptor (UniProt P16410), which is the interaction anti-CTLA-4 antibodies release.
In plain words · CD86 is one of the two B7 molecules on antigen-presenting cells that either wake a T cell up (through CD28) or calm it down (through CTLA-4). Ipilimumab works by stopping CTLA-4 from hogging CD86 and CD80.
CD86 is one of the two B7 molecules on antigen-presenting cells that either wake a T cell up (through CD28) or calm it down (through CTLA-4). Ipilimumab works by stopping CTLA-4 from hogging CD86 and CD80.
Shares the CD28/CTLA-4 ligand role with CD80; no drug in the corpus binds CD86 directly.
No product in this corpus aims at CD86 (B7-2) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1993. Earliest sequence paper UniProt cites for the protein: Azuma et al, Nature, 1993, "B70 antigen is a second ligand for CTLA-4 and CD28". Source.
Sources: HGNC HGNC:1705 (approved symbol, name, aliases and cross-references); UniProt P42081 (protein name, function and tissue specificity)
Shares the CD28/CTLA-4 ligand role with CD80; no drug in the corpus binds CD86 directly.
Query for this target: (TITLE:"CD86" OR ABSTRACT:"CD86" OR TITLE:"B7-2" OR ABSTRACT:"B7-2" OR TITLE:"B7.2" OR ABSTRACT:"B7.2" OR TITLE:"CD28LG2" OR ABSTRACT:"CD28LG2" OR TITLE:"CD86 molecule" OR ABSTRACT:"CD86 molecule") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD86 (B7-2), not a curated reading list.
Shares CD28, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares CD28, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.