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HHLA2 is a B7 relative found on gut, kidney and lung tissue and on many tumours; it can both encourage and restrain T cells depending on the receptor. No drug against it is in the corpus yet.
HHLA2 (chromosome 3q13.13) costimulates T cells through TMIGD2 in the context of TCR-mediated activation, enhancing proliferation and cytokine production through an AKT-dependent cascade; it is expressed at high levels in colon, kidney, testis, lung and pancreas, at lower levels in small intestine, liver and skeletal muscle, and among immune cells in B cells, dendritic cells and macrophages but not T cells (UniProt Q9UM44). B7-H3, B7x and HHLA2 form the third group of the B7-CD28 family, with antagonistic antibodies and agonistic fusion proteins emerging (Janakiram et al. 2017, Immunol Rev).
In plain words · HHLA2 is a B7 relative found on gut, kidney and lung tissue and on many tumours; it can both encourage and restrain T cells depending on the receptor. No drug against it is in the corpus yet.
HHLA2 is a B7 relative found on gut, kidney and lung tissue and on many tumours; it can both encourage and restrain T cells depending on the receptor. No drug against it is in the corpus yet.
A group III B7 family member; its costimulatory receptor is TMIGD2 (CD28H).
No product in this corpus aims at HHLA2 (B7-H7) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1999. Earliest sequence paper UniProt cites for the protein: Mager D.L. et al, Genomics, 1999, "Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3)". Source.
Sources: HGNC HGNC:4905 (approved symbol, name, aliases and cross-references); UniProt Q9UM44 (protein name, function and tissue specificity)
A group III B7 family member; its costimulatory receptor is TMIGD2 (CD28H).
Query for this target: (TITLE:"HHLA2" OR ABSTRACT:"HHLA2" OR TITLE:"B7-H7" OR ABSTRACT:"B7-H7" OR TITLE:"B7H7" OR ABSTRACT:"B7H7" OR TITLE:"B7-H5" OR ABSTRACT:"B7-H5" OR TITLE:"B7y" OR ABSTRACT:"B7y" OR TITLE:"HHLA2 member of B7 family" OR ABSTRACT:"HHLA2 member of B7 family") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HHLA2 (B7-H7), not a curated reading list.
Shares CD28, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares CD28, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.