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The A2A receptor is where adenosine lands on a T cell and tells it to rest. Oral antagonists, cousins of caffeine, are in phase 2 combinations with PD-1 blockade and chemotherapy.
ADORA2A (chromosome 22q11.23) encodes a G-protein-coupled adenosine receptor whose activity is mediated by G proteins that activate adenylyl cyclase (UniProt P29274). Ectonucleotidases and adenosine receptors are broadly expressed and have emerged as immuno-oncology targets, with early-phase trials showing promising results (Allard et al. 2019, Immunol Rev). Ciforadenant is in phase 1b/2 with ipilimumab and nivolumab (NCT05501054), etrumadenant (A2A/A2B) in phase 2 combinations in pancreatic cancer (NCT06048484), and inupadenant in phase 2 with chemotherapy in non-squamous non-small-cell lung cancer (NCT05403385).
In plain words · The A2A receptor is where adenosine lands on a T cell and tells it to rest. Oral antagonists, cousins of caffeine, are in phase 2 combinations with PD-1 blockade and chemotherapy.
The A2A receptor is where adenosine lands on a T cell and tells it to rest. Oral antagonists, cousins of caffeine, are in phase 2 combinations with PD-1 blockade and chemotherapy.
The receptor end of the CD39-CD73-adenosine axis; antagonists are small molecules.
No product in this corpus aims at Adenosine A2A receptor (ADORA2A) yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
First described 1992. Earliest sequence paper UniProt cites for the protein: Tiffany H.L. et al, 1992. Source.
Sources: HGNC HGNC:263 (approved symbol, name, aliases and cross-references); UniProt P29274 (protein name, function and tissue specificity)
The receptor end of the CD39-CD73-adenosine axis; antagonists are small molecules.
Query for this target: (TITLE:"Adenosine A2A receptor" OR ABSTRACT:"Adenosine A2A receptor" OR TITLE:"ADORA2A" OR ABSTRACT:"ADORA2A" OR TITLE:"A2AR" OR ABSTRACT:"A2AR" OR TITLE:"A2A receptor" OR ABSTRACT:"A2A receptor" OR TITLE:"adenosine A2a receptor" OR ABSTRACT:"adenosine A2a receptor" OR TITLE:"RDC8" OR ABSTRACT:"RDC8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Adenosine A2A receptor (ADORA2A), not a curated reading list.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Non-small-cell lung cancer and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.