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CD96 sits on T and NK cells and binds CD155, the same molecule TIGIT reads on tumour cells. It is the least tested of that family; one blocking antibody is in phase 2 platform trials in lung cancer.
CD96 (chromosome 3q13.13) may mediate adhesive interactions of activated T and NK cells in the late phase of the immune response, promoting NK-cell adhesion to targets through PVR (CD155) on the target cell; it is expressed on normal T-cell lines and clones and at very low levels on activated B cells (UniProt P40200). CD155 is the ligand for the co-stimulatory receptor CD226 and the co-inhibitory receptors TIGIT and CD96 (Kučan Brlić et al. 2017). GSK6097608, an anti-CD96 antibody, is being tested in phase 2 platform studies with dostarlimab in non-small-cell lung cancer (NCT05565378, NCT03739710).
In plain words · CD96 sits on T and NK cells and binds CD155, the same molecule TIGIT reads on tumour cells. It is the least tested of that family; one blocking antibody is in phase 2 platform trials in lung cancer.
CD96 sits on T and NK cells and binds CD155, the same molecule TIGIT reads on tumour cells. It is the least tested of that family; one blocking antibody is in phase 2 platform trials in lung cancer.
An immunoglobulin-superfamily receptor of the TIGIT/CD226 axis competing for CD155.
No product in this corpus aims at CD96 yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1992. Earliest sequence paper UniProt cites for the protein: Wang P.L. et al, J. Immunol, 1992, "Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily". Source.
Sources: HGNC HGNC:16892 (approved symbol, name, aliases and cross-references); UniProt P40200 (protein name, function and tissue specificity)
An immunoglobulin-superfamily receptor of the TIGIT/CD226 axis competing for CD155.
Query for this target: (TITLE:"CD96" OR ABSTRACT:"CD96" OR TITLE:"TACTILE" OR ABSTRACT:"TACTILE" OR TITLE:"CD96 molecule" OR ABSTRACT:"CD96 molecule" OR TITLE:"T-cell surface protein tactile" OR ABSTRACT:"T-cell surface protein tactile") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD96, not a curated reading list.
Shares CD155 (PVR), TIGIT blockade, TIGIT, Checkpoint (two meanings) and the tag checkpoint-map.
Shares TIGIT blockade, TIGIT, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Non-small-cell lung cancer and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Immune checkpoint inhibitors, Non-small-cell lung cancer and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Immune checkpoint inhibitors and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.