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CD155 is the molecule on tumour cells that TIGIT and CD96 read; normal tissue barely shows it, many tumours show a lot. Every TIGIT antibody works by breaking the CD155 handshake.
PVR (chromosome 19q13.31) encodes CD155, which mediates NK-cell adhesion and triggers NK effector functions through two NK-cell receptors, CD96 and CD226, at the immunological synapse (UniProt P15151). It is barely or weakly expressed in various normal human tissues but frequently over-expressed in malignant tumours, promotes invasion and migration, is associated with shorter survival, and as the ligand of the co-stimulatory receptor CD226 and the co-inhibitory receptors TIGIT and CD96 it plays a dual role in onco-immunity (Kučan Brlić et al. 2017, Cell Mol Immunol).
In plain words · CD155 is the molecule on tumour cells that TIGIT and CD96 read; normal tissue barely shows it, many tumours show a lot. Every TIGIT antibody works by breaking the CD155 handshake.
CD155 is the molecule on tumour cells that TIGIT and CD96 read; normal tissue barely shows it, many tumours show a lot. Every TIGIT antibody works by breaking the CD155 handshake.
A nectin-like adhesion molecule and the poliovirus receptor; the shared ligand of the DNAM-1/TIGIT/CD96 axis.
No product in this corpus aims at CD155 (PVR) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1989. Earliest sequence paper UniProt cites for the protein: Mendelsohn C.L. et al, Cell, 1989, "Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily". Source.
Sources: HGNC HGNC:9705 (approved symbol, name, aliases and cross-references); UniProt P15151 (protein name, function and tissue specificity)
A nectin-like adhesion molecule and the poliovirus receptor; the shared ligand of the DNAM-1/TIGIT/CD96 axis.
Query for this target: (TITLE:"CD155" OR ABSTRACT:"CD155" OR TITLE:"PVR" OR ABSTRACT:"PVR" OR TITLE:"poliovirus receptor" OR ABSTRACT:"poliovirus receptor" OR TITLE:"Necl-5" OR ABSTRACT:"Necl-5" OR TITLE:"NECL5" OR ABSTRACT:"NECL5" OR TITLE:"PVS" OR ABSTRACT:"PVS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD155 (PVR), not a curated reading list.
Shares CD112 (nectin-2), TIGIT blockade, TIGIT, Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.