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CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.
NECTIN2 (chromosome 19q13.32) is a modulator of T-cell signalling that acts as a costimulator or a coinhibitor depending on the receptor it binds: through CD226 it stimulates proliferation and the production of IL-2, IL-5, IL-10, IL-13 and interferon gamma, through PVRIG it inhibits proliferation, and the two interactions are competitive; it is ubiquitously expressed and a probable cell-adhesion protein (UniProt Q92692). TIGIT binds PVR (CD155) or NECTIN2 (CD112) on antigen-presenting cells and sends inhibitory signals to the T cell or NK cell (UniProt Q495A1).
In plain words · CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.
CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.
The second ligand of the TIGIT axis and the sole established ligand of PVRIG.
No product in this corpus aims at CD112 (nectin-2) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1995. Earliest sequence paper UniProt cites for the protein: Eberle et al, Gene, 1995, "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene". Source.
Sources: HGNC HGNC:9707 (approved symbol, name, aliases and cross-references); UniProt Q92692 (protein name, function and tissue specificity)
The second ligand of the TIGIT axis and the sole established ligand of PVRIG.
Query for this target: (TITLE:"CD112" OR ABSTRACT:"CD112" OR TITLE:"nectin-2" OR ABSTRACT:"nectin-2" OR TITLE:"NECTIN2" OR ABSTRACT:"NECTIN2" OR TITLE:"PVRL2" OR ABSTRACT:"PVRL2" OR TITLE:"PRR2" OR ABSTRACT:"PRR2" OR TITLE:"HVEB" OR ABSTRACT:"HVEB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD112 (nectin-2), not a curated reading list.
Shares CD155 (PVR), TIGIT blockade, TIGIT, Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.