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HLA-E is the self badge that NKG2A on NK cells reads. Tumours raise it to escape NK cells; monalizumab blocks the reader rather than the badge.
HLA-E (chromosome 6p22.1) is a non-classical MHC class Ib molecule involved in self versus non-self discrimination that, with beta-2 microglobulin, binds nonamer signal-sequence peptides from classical class Ia molecules and is read by the CD94/NKG2A inhibitory receptor (UniProt P13747). Outside lymphoid tissue its expression is restricted to endothelial cells of all vessel types; in lymphoid organs it is expressed on endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (protein level).
In plain words · HLA-E is the self badge that NKG2A on NK cells reads. Tumours raise it to escape NK cells; monalizumab blocks the reader rather than the badge.
HLA-E is the self badge that NKG2A on NK cells reads. Tumours raise it to escape NK cells; monalizumab blocks the reader rather than the badge.
The ligand of NKG2A (KLRC1); the same complex can activate through NKG2C.
No product in this corpus aims at HLA-E yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1988. Earliest sequence paper UniProt cites for the protein: Mizuno et al, J. Immunol, 1988, "Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene". Source.
Sources: HGNC HGNC:4962 (approved symbol, name, aliases and cross-references); UniProt P13747 (protein name, function and tissue specificity)
The ligand of NKG2A (KLRC1); the same complex can activate through NKG2C.
Query for this target: (TITLE:"HLA-E" OR ABSTRACT:"HLA-E" OR TITLE:"major histocompatibility complex, class I, E" OR ABSTRACT:"major histocompatibility complex, class I, E" OR TITLE:"HLA class I histocompatibility antigen, alpha chain E" OR ABSTRACT:"HLA class I histocompatibility antigen, alpha chain E") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HLA-E, not a curated reading list.
Shares HLA-A, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares NKG2A (KLRC1), Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares HLA-A, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.