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PVRIG is a brake on killer T cells and NK cells that reads CD112 on tumour cells, a cousin of the TIGIT pair. The antibody COM701 blocks it and is being tested in ovarian cancer.
PVRIG (chromosome 7q22.1) is a cell-surface receptor for NECTIN2 (CD112) that may act as a co-inhibitory receptor suppressing T-cell receptor signals, inhibits T-cell proliferation after NECTIN2 binding and competes with CD226 for it; it is expressed at low levels on freshly isolated T and NK cells, predominantly memory and effector CD8 T cells and both CD16-positive and CD16-negative NK cells, and not on B cells, naive or helper T cells, monocytes or neutrophils (UniProt Q6DKI7). COM701 completed a phase 1/2 study with the TIGIT antibody BMS-986207 and nivolumab (NCT04570839) and is recruiting in relapsed platinum-sensitive ovarian cancer (NCT06888921).
In plain words · PVRIG is a brake on killer T cells and NK cells that reads CD112 on tumour cells, a cousin of the TIGIT pair. The antibody COM701 blocks it and is being tested in ovarian cancer.
PVRIG is a brake on killer T cells and NK cells that reads CD112 on tumour cells, a cousin of the TIGIT pair. The antibody COM701 blocks it and is being tested in ovarian cancer.
An immunoglobulin-domain receptor with an ITIM-like tail; part of the CD226/TIGIT/CD96/PVRIG axis over CD155 and CD112.
No product in this corpus aims at PVRIG (CD112R) yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:32190 (approved symbol, name, aliases and cross-references); UniProt Q6DKI7 (protein name, function and tissue specificity)
An immunoglobulin-domain receptor with an ITIM-like tail; part of the CD226/TIGIT/CD96/PVRIG axis over CD155 and CD112.
Query for this target: (TITLE:"PVRIG" OR ABSTRACT:"PVRIG" OR TITLE:"CD112R" OR ABSTRACT:"CD112R" OR TITLE:"PVR related immunoglobulin domain containing" OR ABSTRACT:"PVR related immunoglobulin domain containing" OR TITLE:"C7orf15" OR ABSTRACT:"C7orf15") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PVRIG (CD112R), not a curated reading list.
Shares CD112 (nectin-2), TIGIT blockade, TIGIT, Checkpoint (two meanings) and the tag checkpoint-map.
Shares TIGIT blockade, TIGIT, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab, Immune checkpoint inhibitors and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Nivolumab and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle, Ovarian cancer and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.