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BTLA is a brake on T and B cells that is pressed by HVEM, a molecule many tumours carry. An antibody that blocks it is being tested with PD-1 blockade in small-cell lung cancer.
BTLA (chromosome 3q13.2) is an inhibitory receptor on lymphocytes that negatively regulates antigen-receptor signalling through the phosphatases SHP-1 and SHP-2, and can interact with TNFRSF14 (HVEM) in cis on the same cell or in trans on other cells; in cis it appears to restrain trans interactions in naive T cells (UniProt Q7Z6A9). Its partner HVEM binds four distinct ligands, LIGHT, lymphotoxin-alpha, BTLA and CD160, forming a network of stimulatory and inhibitory signals (UniProt Q92956). Tifcemalimab, an anti-BTLA antibody, is in a phase 3 consolidation study with toripalimab in limited-stage small-cell lung cancer (ClinicalTrials.gov NCT06095583).
In plain words · BTLA is a brake on T and B cells that is pressed by HVEM, a molecule many tumours carry. An antibody that blocks it is being tested with PD-1 blockade in small-cell lung cancer.
BTLA is a brake on T and B cells that is pressed by HVEM, a molecule many tumours carry. An antibody that blocks it is being tested with PD-1 blockade in small-cell lung cancer.
An immunoglobulin-superfamily receptor with ITIM motifs; the HVEM interaction is the only established ligand pair.
No product in this corpus aims at BTLA yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 2003. Earliest sequence paper UniProt cites for the protein: Watanabe et al, Nat. Immunol, 2003, "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Source.
Sources: HGNC HGNC:21087 (approved symbol, name, aliases and cross-references); UniProt Q7Z6A9 (protein name, function and tissue specificity)
An immunoglobulin-superfamily receptor with ITIM motifs; the HVEM interaction is the only established ligand pair.
Query for this target: (TITLE:"BTLA" OR ABSTRACT:"BTLA" OR TITLE:"B and T lymphocyte associated" OR ABSTRACT:"B and T lymphocyte associated" OR TITLE:"CD272" OR ABSTRACT:"CD272" OR TITLE:"BTLA1" OR ABSTRACT:"BTLA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BTLA, not a curated reading list.
Shares Checkpoint (two meanings), PD-1 / PD-L1 immune checkpoint & T-cell activation and the tag checkpoint-map.
Shares Checkpoint (two meanings), PD-1 / PD-L1 immune checkpoint & T-cell activation and the tag checkpoint-map.
Shares Checkpoint (two meanings), Immune checkpoint inhibitors and the tag checkpoint-map.
Shares Checkpoint (two meanings), Immune checkpoint inhibitors and the tag checkpoint-map.
Shares Checkpoint (two meanings), Immune checkpoint inhibitors and the tag checkpoint-map.
Shares Checkpoint (two meanings), Immune checkpoint inhibitors and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.