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FGL1 is a liver protein that some tumours secrete; it binds LAG-3 on T cells and switches them off, separately from the MHC class II route. It explains part of how LAG-3 blockade works.
FGL1 (chromosome 8p22) is an immune-suppressive molecule that inhibits antigen-specific T-cell activation as a ligand of LAG-3, initiating signalling that inhibits the T-cell receptor in the immunological synapse; it binds LAG-3 independently of MHC class II, is liver-specific under normal conditions and is secreted by hepatocytes and certain tumour cells (UniProt Q08830, Q15116 context from P18627).
In plain words · FGL1 is a liver protein that some tumours secrete; it binds LAG-3 on T cells and switches them off, separately from the MHC class II route. It explains part of how LAG-3 blockade works.
FGL1 is a liver protein that some tumours secrete; it binds LAG-3 on T cells and switches them off, separately from the MHC class II route. It explains part of how LAG-3 blockade works.
A secreted fibrinogen-family protein; the second LAG-3 ligand after MHC class II.
No product in this corpus aims at FGL1 yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1993. Earliest sequence paper UniProt cites for the protein: Yamamoto et al, Biochem. Biophys. Res. Commun, 1993, "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1". Source.
Sources: HGNC HGNC:3695 (approved symbol, name, aliases and cross-references); UniProt Q08830 (protein name, function and tissue specificity)
A secreted fibrinogen-family protein; the second LAG-3 ligand after MHC class II.
Query for this target: (TITLE:"FGL1" OR ABSTRACT:"FGL1" OR TITLE:"fibrinogen like 1" OR ABSTRACT:"fibrinogen like 1" OR TITLE:"HFREP-1" OR ABSTRACT:"HFREP-1" OR TITLE:"hepassocin" OR ABSTRACT:"hepassocin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGL1, not a curated reading list.
Shares Checkpoint (two meanings), PD-1 / PD-L1 immune checkpoint & T-cell activation and the tag checkpoint-map.
Shares Checkpoint (two meanings), PD-1 / PD-L1 immune checkpoint & T-cell activation and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.
Shares Checkpoint (two meanings) and the tag checkpoint-map.