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BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
A kinetochore kinase of the spindle assembly checkpoint, alongside MPS1 (TTK) and BUB1B.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"BUB1" OR ABSTRACT:"BUB1" OR TITLE:"BUB1 mitotic checkpoint serine/threonine kinase" OR ABSTRACT:"BUB1 mitotic checkpoint serine/threonine kinase" OR TITLE:"hBUB1" OR ABSTRACT:"hBUB1" OR TITLE:"BUB1L" OR ABSTRACT:"BUB1L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BUB1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/bub1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/bub1.json. Licence CC BY-NC 4.0.