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Cancers
Non-Hodgkin lymphoma (all types)
Biology and targets

Cancers·Non-Hodgkin lymphoma (all types)

Biology and targetsNon-Hodgkin lymphoma (all types)

Back to the Non-Hodgkin lymphoma hub →257 targets · 15 pathways

The molecular landscape: the targets and how often each appears, the pathways, the mechanics stages and the preclinical models.

Overview Types and stages Symptoms and diagnosis Treatment Trials and papers Biology and targets Countries and centres Decisions and support Pipeline and open problems Data

Biology and targets

Targets

257

The targets of this cancer's medicines and the ones linked to it directly.

ADRM1 AFF1 ANKRD11 ARID1A ARID1B ARID5B ASXL1 ATM ATP4A ATP4B B2M BAK1 BCL-2 BCL10 BCL11A BCL11B BCL6 BCL7A BCOR BIM (BCL2L11)BIRC3 BLK BLM BTG1 BTG2 BTK (Bruton tyrosine kinase)C11orf65 CARD11 CASP10 CASP8 CCND1 CCND3 CCR4 CD19 CD20 CD22 CD3 CD30 CD38 CD3D CD3G CD47 CD52 CD58 CD79A CD79b CDKN2A CEP43 and 209 more →

How often this target appears

Pathways

15

Antigen presentation & immune editing B-cell receptor / BTK signalling (to NF-κB)CD47 / SIRPα (the 'don't eat me' signal)Clonal evolution & minimal residual disease Epigenetic reprogramming Inflammation & NF-κB Intrinsic apoptosis (BCL-2 family)JAK-STAT signalling MYC Oncogenic viruses PD-1 / PD-L1 immune checkpoint & T-cell activation Resistance routes: how a blocked pathway comes back The germinal centre reaction Transcriptional machinery & addiction Tumour microenvironment (TME)

The mechanics of cancer, stage by stage →

ProvenanceLast edited 2026-09-17 · Jude Gomila · Reverse links for orphaned trials · diff · file

Wikipedia

Non-Hodgkin lymphoma

Sources & links

NCI: Lymphoma
GLOBOCAN 2020 (Sung 2021)
Lymphoma Action: helpline services
Lymphoma Action: questions to ask your medical team about lymphoma
Lymphoma Action: follow-up after lymphoma treatment
Lymphoma Action: infections, risk and prevention
Lymphoma Action: neutropenia (low neutrophils)
Lymphoma Action: cancer-related fatigue
Lymphoma Action: lymphoma, work and you
Maggie's: support and information
NHS: non-Hodgkin lymphoma
NHS: non-Hodgkin lymphoma, symptoms
NHS: non-Hodgkin lymphoma, treatment
Macmillan: lymphoma
Macmillan: non-Hodgkin lymphoma
Cancer Research UK: living with non-Hodgkin lymphoma
Cancer Research UK: tests to diagnose non-Hodgkin lymphoma
Cancer Research UK: follow-up for non-Hodgkin lymphoma
NICE NG52: non-Hodgkin's lymphoma, diagnosis and management
NICE NG47: haematological cancers, improving outcomes
Lymphoma Action: lymphoma staging
Lymphoma Action: biopsy
Lymphoma Action: CT and PET/CT scans
Lymphoma Action: waiting for test and scan results
Lymphoma Action: your medical team
Lymphoma Action: taking part in a clinical trial
Lymphoma Action: caring for someone who has lymphoma
NHS: carer's assessments
NHS: when to use 111
NHS: when to call 999
NHS: sepsis
Macmillan: metastatic spinal cord compression
Macmillan: superior vena cava obstruction
NICE NG234: spinal metastases and metastatic spinal cord compression
WHO Classification of Haematolymphoid Tumours, 5th edition: lymphoid neoplasms (Alaggio, Leukemia 2022)
International Consensus Classification of Mature Lymphoid Neoplasms (Campo, Blood 2022)
Lymphoma incidence, survival and prevalence 2004 to 2014, subtype analyses from the UK Haematological Malignancy Research Network (Smith, Br J Cancer 2015)
Lugano classification: recommendations for initial evaluation, staging and response assessment of Hodgkin and non-Hodgkin lymphoma (Cheson, J Clin Oncol 2014)
SEER Cancer Stat Facts: non-Hodgkin lymphoma (United States incidence, mortality and relative survival)
Cancer Research UK: non-Hodgkin lymphoma statistics (incidence, mortality, survival)
NCI PDQ: adult non-Hodgkin lymphoma treatment (health professional version)
NCI PDQ: adult non-Hodgkin lymphoma treatment (patient version)
Lymphoma Action: types of lymphoma (UK patient charity)
Lymphoma Research Foundation: about lymphoma
GLOBOCAN 2020 global cancer statistics (Sung, CA Cancer J Clin 2021)
NICE NG12: suspected cancer, haematological cancers (1.10.1 to 1.10.9)
Lymphoma Action: the UK lymphoma charity
Cancer Research UK: non-Hodgkin lymphoma statistics

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