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CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.95).
In plain words · CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.
CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation.
No product in this corpus aims at CD79A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1988. Earliest sequence paper UniProt cites for the protein: Sakaguchi et al, EMBO J, 1988, "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties". Source.
Sources: HGNC HGNC:1698 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11912 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105369 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.53, non-Hodgkin lymphoma 0.51, skin cancer 0.50 (GraphQL API, CC0))
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signalling during development of immature B-cells. Location: Cell membrane (UniProt). Locus 19q13.2 (HGNC).
Query for this target: (TITLE:"CD79A" OR ABSTRACT:"CD79A" OR TITLE:"CD79a molecule" OR ABSTRACT:"CD79a molecule" OR TITLE:"B-cell antigen receptor complex-associated protein alpha chain" OR ABSTRACT:"B-cell antigen receptor complex-associated protein alpha chain" OR TITLE:"MB-1" OR ABSTRACT:"MB-1" OR TITLE:"Ig-alpha" OR ABSTRACT:"Ig-alpha" OR TITLE:"MB1" OR ABSTRACT:"MB1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD79A, not a curated reading list.