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ANKRD11 (Ankyrin repeat domain-containing protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Malignant Lymphoma.
In plain words · ANKRD11 (Ankyrin repeat domain-containing protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
ANKRD11 (Ankyrin repeat domain-containing protein 11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
No product in this corpus aims at ANKRD11 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2003. Earliest sequence paper UniProt cites for the protein: Powell J.A. et al, 2003, "ANKRD11 and ANKRD12 are novel 9kb genes encoding nuclear-located proteins with ankyrin domains". Source.
Sources: HGNC HGNC:21316 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6UB99 (protein name, function text, keywords and locations (REST API)); IntOGen ANKRD11 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis. Location: Nucleus (UniProt). Locus 16q24.3 (HGNC).
Query for this target: (TITLE:"ANKRD11" OR ABSTRACT:"ANKRD11" OR TITLE:"ankyrin repeat domain 11" OR ABSTRACT:"ankyrin repeat domain 11" OR TITLE:"Ankyrin repeat domain-containing protein 11" OR ABSTRACT:"Ankyrin repeat domain-containing protein 11" OR TITLE:"LZ16" OR ABSTRACT:"LZ16" OR TITLE:"T13" OR ABSTRACT:"T13" OR TITLE:"ANCO1" OR ABSTRACT:"ANCO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ANKRD11, not a curated reading list.