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C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.07, genetic association 0.91, somatic mutation 0.87).
In plain words · C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.
C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.
No product in this corpus aims at C11orf65 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:28519 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NCR3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166323 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.62, gastric cancer 0.54, prostate cancer 0.54, urinary bladder cancer 0.53, ovarian cancer 0.55, non-Hodgkin lymphoma 0.54 (GraphQL API, CC0))
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network. Location: Cytoplasm, cytosol; Mitochondrion outer membrane (UniProt). Locus 11q22.3 (HGNC).
Query for this target: (TITLE:"C11orf65" OR ABSTRACT:"C11orf65" OR TITLE:"chromosome 11 open reading frame 65" OR ABSTRACT:"chromosome 11 open reading frame 65" OR TITLE:"MGC33948" OR ABSTRACT:"MGC33948") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about C11orf65, not a curated reading list.