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Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.
SIGLEC10 (chromosome 19q13.41) is a sialic-acid-binding immunoglobulin-like lectin that preferentially binds alpha-2,3- or alpha-2,6-linked sialic acid and seems to act as an inhibitory receptor in the immune response, recruiting cytoplasmic phosphatases through its ITIMs on ligand-induced phosphorylation; it is expressed by peripheral blood leukocytes (eosinophils, monocytes and an NK-cell subpopulation) and in lymph node, lung, ovary and appendix (UniProt Q96LC7). The CD24-Siglec-10 interaction inhibits macrophage phagocytosis and NK cytotoxicity (Panagiotou et al. 2022).
In plain words · Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.
Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.
An ITIM-bearing Siglec; the receptor half of the CD24 pair.
No product in this corpus aims at Siglec-10 yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 2001. Earliest sequence paper UniProt cites for the protein: Yousef G.M. et al, Biochem. Biophys. Res. Commun, 2001, "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants". Source.
Sources: HGNC HGNC:15620 (approved symbol, name, aliases and cross-references); UniProt Q96LC7 (protein name, function and tissue specificity)
An ITIM-bearing Siglec; the receptor half of the CD24 pair.
Query for this target: (TITLE:"Siglec-10" OR ABSTRACT:"Siglec-10" OR TITLE:"SIGLEC10" OR ABSTRACT:"SIGLEC10" OR TITLE:"SIGLEC-10" OR ABSTRACT:"SIGLEC-10" OR TITLE:"sialic acid binding Ig like lectin 10" OR ABSTRACT:"sialic acid binding Ig like lectin 10" OR TITLE:"SLG2" OR ABSTRACT:"SLG2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Siglec-10, not a curated reading list.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.