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CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.
CD24 (chromosome 6q21) is a small GPI-anchored glycoprotein expressed on B cells and the T-cell surface and in erythroleukaemia and small-cell lung carcinoma cell lines; it modulates B-cell activation (UniProt P25063). Normally expressed by immune, epithelial, neural and muscle cells, its interaction with Siglec-10 has been implicated in tumour immune evasion, inhibiting macrophage-mediated phagocytosis as well as NK-cell cytotoxicity; monoclonal antibodies against CD24 have shown clinical safety in two trials, with limited efficacy data (Panagiotou et al. 2022). IMM47, an anti-CD24 antibody, entered a phase 1 study in advanced solid tumours (NCT05985083, status unknown).
In plain words · CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.
CD24 is a second 'don't eat me' badge after CD47: tumours show it to Siglec-10 on macrophages, which then leave them alone. Blocking antibodies are in first-in-human trials.
A heavily glycosylated GPI-anchored surface protein; the ligand of Siglec-10.
No product in this corpus aims at CD24 yet. Checkpoint drugs are antibodies that cover one side of an immune ‘stand down’ handshake so T cells stay active.
First described 1991. Earliest sequence paper UniProt cites for the protein: Kay et al, J. Immunol, 1991, "CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor". Source.
Sources: HGNC HGNC:1645 (approved symbol, name, aliases and cross-references); UniProt P25063 (protein name, function and tissue specificity)
A heavily glycosylated GPI-anchored surface protein; the ligand of Siglec-10.
Query for this target: (TITLE:"CD24" OR ABSTRACT:"CD24" OR TITLE:"CD24 molecule" OR ABSTRACT:"CD24 molecule" OR TITLE:"signal transducer CD24" OR ABSTRACT:"signal transducer CD24" OR TITLE:"CD24A" OR ABSTRACT:"CD24A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD24, not a curated reading list.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.