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Large immune cells that engulf debris, microbes and dead cells and coordinate inflammation. Tumours recruit and retrain them: tumour-associated macrophages can make up half the cells in some tumours, where they feed blood-vessel growth and suppress T cells, and cancer cells display CD47 as a 'don't eat me' signal to avoid being engulfed.
Macrophages can be pro-inflammatory and tumour-killing or tissue-repairing and immunosuppressive, and tumours push them towards the latter; tumour-associated macrophages can make up half the cells in some tumours, where they promote blood-vessel growth, suppress T cells, help cancer cells invade, and take up ADC payloads that contribute to side effects. Cancer cells display CD47, a 'don't eat me' signal, to stop macrophages engulfing them, and CD47 blockers are in trials. Efforts to reprogramme macrophages (CSF1R inhibitors, CD40 agonists, CAR-macrophages) have been harder to translate than T-cell approaches.
In plain words · CD47 is the 'don't eat me' signal: it binds SIRP-alpha on macrophages to stop them engulfing the cell, and over 90% of AML blasts and large B-cell lymphoma cells display it. Blocking it should let macrophages eat tumour cells, but red cells carry CD47 too, so anaemia is built in, and the lead antibody magrolimab was dropped after failed trials.
Showing the target this term concerns: CD47.
Shares Balkwill and Mantovani 2001: inflammation and cancer, back to Virchow?, Inflammation, Immune system, Microenvironment and inflammation: tumours as wounds that do not heal.
Shares Myeloid-derived suppressor cells (MDSCs), Tumour-associated macrophages (TAMs), CD47, CAR-NK & CAR-macrophage.
Shares Tumour-associated macrophages (TAMs), Microenvironment and inflammation: tumours as wounds that do not heal, Tumour microenvironment (TME).
Shares Inflammation, Immune system.
Shares Myeloid-derived suppressor cells (MDSCs), Tumour-associated macrophages (TAMs), Tumour microenvironment (TME).
Shares Balkwill and Mantovani 2001: inflammation and cancer, back to Virchow?, Inflammation.
Shares Balkwill and Mantovani 2001: inflammation and cancer, back to Virchow?, Inflammation, Microenvironment and inflammation: tumours as wounds that do not heal.