Loading
IL-10 is a calming signal that many immune cells release; tumours and the viruses behind them raise it to keep the immune system quiet. Oddly, the main cancer drug built on it gave more IL-10 rather than less, and failed.
IL10 (chromosome 1q32.1) encodes a major immune-regulatory cytokine with profound anti-inflammatory functions that binds a heterotetrameric receptor of IL10RA and IL10RB and signals through JAK1 to STAT3; it is produced by T cells, macrophages, mast cells and other cell types (UniProt P22301). HPV up-regulates IL-10 and TGF-beta 1 to produce a local immunosuppressive environment (Torres-Poveda et al. 2014). Pegilodecakin, a pegylated IL-10 given to stimulate CD8 T cells, was tested against FOLFOX in pancreatic cancer in phase 3 (NCT02923921); its CYPRESS-1 and CYPRESS-2 studies with PD-1 antibodies closed early because the risk-benefit ratio was unfavourable (NCT03382899, NCT03382912). The corpus's LB4330 fuses IL-10 to a Claudin 18.2 antibody, again as an agonist.
In plain words · IL-10 is a calming signal that many immune cells release; tumours and the viruses behind them raise it to keep the immune system quiet. Oddly, the main cancer drug built on it gave more IL-10 rather than less, and failed.
IL-10 is a calming signal that many immune cells release; tumours and the viruses behind them raise it to keep the immune system quiet. Oddly, the main cancer drug built on it gave more IL-10 rather than less, and failed.
A soluble cytokine, not a receptor; listed with the checkpoint families as a microenvironment brake because the cited review frames it so.
No product in this corpus aims at Interleukin-10 (IL10) yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1991. Earliest sequence paper UniProt cites for the protein: Vieira et al, Proc. Natl. Acad. Sci. U.S.A, 1991, "Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI". Source.
Sources: HGNC HGNC:5962 (approved symbol, name, aliases and cross-references); UniProt P22301 (protein name, function and tissue specificity)
A soluble cytokine, not a receptor; listed with the checkpoint families as a microenvironment brake because the cited review frames it so.
Query for this target: (TITLE:"Interleukin-10" OR ABSTRACT:"Interleukin-10" OR TITLE:"IL10" OR ABSTRACT:"IL10" OR TITLE:"IL-10" OR ABSTRACT:"IL-10" OR TITLE:"interleukin 10" OR ABSTRACT:"interleukin 10" OR TITLE:"CSIF" OR ABSTRACT:"CSIF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Interleukin-10 (IL10), not a curated reading list.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Macrophage, Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.
Shares Checkpoint (two meanings), The cancer-immunity cycle and the tag checkpoint-map.