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A short, widely cited essay reviving Virchow's 1863 observation that tumours are full of white blood cells, arguing that the inflammatory cells and cytokines in tumours help them grow rather than fight them.
Balkwill and Mantovani revisited Rudolf Virchow's observation of leukocytes in tumours and assembled the modern evidence: that chronic inflammatory conditions predispose to cancer, that tumours recruit macrophages and other inflammatory cells whose cytokines and chemokines promote growth, angiogenesis and invasion, and that inflammatory mediators such as TNF, IL-1 and IL-6 have tumour-promoting roles. They noted the reduced colorectal cancer risk in long-term users of non-steroidal anti-inflammatory drugs as clinical support and proposed anti-inflammatory strategies for prevention and treatment.
Together with the 2002 Nature review this essay put inflammation on the cancer research agenda; the tumour-associated macrophage and IL-6 work that followed, and the aspirin prevention trials, trace back to it.
Shares Grivennikov, Greten and Karin 2010: immunity, inflammation and cancer, Inflammation, Microenvironment and inflammation: tumours as wounds that do not heal, Inflammation & NF-κB.
Shares Tumour-associated macrophages (TAMs), Coussens and Werb 2002: inflammation and cancer, Microenvironment and inflammation: tumours as wounds that do not heal.
Shares Grivennikov, Greten and Karin 2010: immunity, inflammation and cancer, Microenvironment and inflammation: tumours as wounds that do not heal.
Shares Macrophage, Inflammation.
Shares Coussens and Werb 2002: inflammation and cancer, Macrophage, Inflammation.
Shares Aspirin for cancer prevention and adjuvant therapy, Microenvironment and inflammation: tumours as wounds that do not heal.
Shares Tumour-associated macrophages (TAMs), Macrophage, Microenvironment and inflammation: tumours as wounds that do not heal, Inflammation & NF-κB.