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Chronic inflammation supplies growth factors, survival signals, and mutagens that help cancers start and grow.
Tumour-promoting inflammation is the enabling characteristic by which chronic inflammation supplies growth factors, survival signals and mutagens that help cancers start and grow. The signalling runs through IL-6/STAT3, TNF/NF-κB, COX-2/PGE2 and inflammasomes, described in the Inflammation & NF-κB, JAK-STAT signalling and Microbiome-tumour interactions pathways, and infection-driven cancers (HPV, HBV, Helicobacter pylori) are the clearest examples, as the Oncogenic viruses pathway explains. Prevention rests on HPV & HBV vaccination, anti-infectives and aspirin, covered under Chemoprevention & risk-reducing surgery, while BTK inhibitors shut down NF-κB in B-cell cancers. Readers meet this characteristic from the Hallmarks of Cancer overview and from the Inflammation entry.
Showing the technology this term belongs to: Chemoprevention & risk-reducing surgery.
Shares COX-2 (PTGS2), Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Microbiome-tumour interactions, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.