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Tumours grow their own blood supply, or co-opt existing vessels, to get oxygen and nutrients.
Inducing or accessing vasculature is the hallmark by which tumours grow their own blood supply, or co-opt existing vessels, to obtain oxygen and nutrients. The mechanisms are VEGF-driven sprouting angiogenesis, vessel co-option and vasculogenic mimicry, described in the VEGF angiogenesis and VHL / HIF oxygen sensing pathways, with VEGF / VEGFR and HIF-2α as the linked targets. Anti-angiogenic therapy modestly extends survival on its own and enables immunotherapy by normalising vessels, while HIF-2α inhibition acts upstream in VHL-deficient renal cell carcinoma. Readers meet this hallmark from the Hallmarks of Cancer overview and the 2000 hallmarks paper, from the Angiogenesis entry and the angiogenic switch pathway, and from the Judah Folkman biography.
In plain words · The signal tumours use to grow their own blood supply. Blocking it starves tumours and, surprisingly, helps immunotherapy work.
Showing the target this term concerns: VEGF / VEGFR.
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Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares Hallmarks of Cancer, VHL / HIF oxygen sensing, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.