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Cancer cells bypass the division limit set by shortening telomeres, usually by reactivating telomerase.
Enabling replicative immortality is the hallmark by which cancer cells bypass the division limit imposed by shortening telomeres, usually by reactivating telomerase. Most tumours do this through TERT reactivation and a minority through the ALT route, as described in the Telomere maintenance & replicative immortality pathway, while the Cellular senescence pathway explains the barrier being evaded. Imetelstat is the first telomerase inhibitor to be approved (MDS, 2024), and the linked TERT promoter mutation entry covers the mutations that serve as diagnostic biomarkers. Readers reach this hallmark from the Hallmarks of Cancer overview, the 2000 hallmarks paper and the telomere maintenance pathway.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares Hallmarks of Cancer, Cellular senescence and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.