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Cancer cells keep telling themselves to divide, by making their own growth signals or jamming the receptors on.
Sustaining proliferative signalling is the hallmark by which cancer cells keep instructing themselves to divide, either by producing their own growth signals or by locking growth receptors in the on position. It is achieved through receptor mutation or amplification (EGFR, HER2, ALK), downstream activation (KRAS, BRAF, PIK3CA) or autocrine ligand production, and it runs through the RAS / RAF / MEK / ERK (MAPK), PI3K / AKT / mTOR and MYC pathways. This is the hallmark behind Small-molecule kinase inhibitors, Monoclonal antibodies such as HER2 antibodies, and KRAS & RAS inhibitors, and it underpins the concept of Oncogene addiction. Readers reach it from the Hallmarks of Cancer overview and the original 2000 hallmarks paper, and from the Oncogene, Growth signal and Proliferation entries.
In plain words · A growth receptor that is mutated in some lung cancers and overproduced in others; the first great success of targeted pills.
Showing the target this term concerns: EGFR.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.