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Resisting cell death is the hallmark by which cancer cells disable their self-destruct programmes, chiefly apoptosis.
Resisting cell death is the hallmark by which cancer cells disable their own self-destruct programmes, chiefly apoptosis. It is achieved through BCL-2 family overexpression, p53 loss, IAP upregulation and dependence on autophagy, which is why the linked targets are BCL-2 and TP53 and the linked pathways are Intrinsic apoptosis (BCL-2 family), Autophagy, and Ferroptosis & regulated cell death. BH3 mimetics such as Venetoclax restore apoptosis, while ferroptosis and necroptosis are alternative death routes now being exploited. Readers meet this hallmark from the Hallmarks of Cancer overview, the 2000 hallmarks paper, the Apoptosis entry and the ferroptosis pathway page.
In plain words · A protein that stops cells from self-destructing. Venetoclax removes that protection and has transformed leukaemia treatment.
Showing the target this term concerns: BCL-2.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories, TP53 and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories, TP53 and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.