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Cells that have permanently stopped dividing but stay alive and secrete inflammatory signals, helping nearby cancer cells grow and resist treatment.
Senescent cells, a hallmark added in 2022, are cells that have permanently stopped dividing but stay alive and secrete inflammatory signals, helping nearby cancer cells grow and resist treatment. The senescence-associated secretory phenotype arises from both stromal and tumour cells after therapy, and the underlying biology is laid out in the Cellular senescence pathway. Senolytic drugs aim to clear these cells in a one-two punch after cancer treatment, the strategy explored in the idea One-two punch: clear senescent cells after chemotherapy. Readers meet this hallmark from the Hallmarks of Cancer overview and from the 2022 hallmarks paper that added phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells to the framework.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Cellular senescence and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.