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Cancer cells escape the normal rule that mature cells stay what they are: they dedifferentiate, transdifferentiate, or refuse to mature.
Unlocking phenotypic plasticity, a hallmark added in 2022, describes how cancer cells escape the rule that mature cells stay what they are: they dedifferentiate, transdifferentiate or refuse to mature. Examples are lineage plasticity under therapy (neuroendocrine transformation in prostate and lung cancer), dedifferentiation in melanoma and thyroid cancer and blocked differentiation in leukaemia, covered in the Histologic transformation entry. The responses are differentiation therapy (ATRA, menin inhibitors) and plasticity-blocking epigenetic drugs, which is why Menin, EZH2 and DLL3 are the linked targets. Readers reach it from the Hallmarks of Cancer overview, the 2022 hallmarks paper and the Lineage plasticity & neuroendocrine transformation pathway.
In plain words · A scaffold protein that certain leukaemias need to keep their genes switched on; the first drug against it was approved in 2024.
Showing the target this term concerns: Menin.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories, Epigenetic reprogramming and the tag hallmark.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.