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Cancers can change behaviour, including becoming drug-tolerant, without any new mutation, by rewriting the chemical tags that control which genes are read.
Non-mutational epigenetic reprogramming, a hallmark added in 2022, is the capacity of cancers to change their phenotype, including becoming drug-tolerant, without any new mutation, by rewriting the chemical tags that control which genes are read. It covers drug-tolerant persister states, microenvironment-induced chromatin changes and epigenetic silencing of tumour suppressors and antigens, described in the Epigenetic reprogramming and SWI/SNF chromatin remodelling pathways. The changes are reversible in principle, so Epigenetic drugs (hypomethylating agents, HDAC, EZH2 and BET inhibitors) and epigenetic priming before immunotherapy are the responses, read out by DNA methylation profiling. Readers meet it from the Hallmarks of Cancer overview and the Epigenetic therapy roadmap.
Showing the technology this term belongs to: Epigenetic drugs (HDAC, DNMT, EZH2, IDH, menin, BET).
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories, Epigenetic reprogramming and the tag hallmark.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.