Loading
Cancer cells rewire their metabolism to build biomass fast, burning glucose inefficiently and gorging on glutamine and lipids.
Reprogramming cellular metabolism is the hallmark by which cancer cells rewire their metabolism to build biomass quickly, burning glucose inefficiently and consuming large amounts of glutamine and lipids. The Warburg effect and its relatives define this hallmark, which is described in the Cancer metabolism, VHL / HIF oxygen sensing and KEAP1-NRF2 antioxidant pathways. It is exploited clinically by FDG PET for imaging, by antimetabolite chemotherapy and by inhibitors of IDH1 / IDH2, whereas broader metabolic drugs have struggled against metabolic plasticity. Readers meet this hallmark from the Hallmarks of Cancer overview, the Cancer metabolism, Glutamine addiction and lipid metabolism pathway pages, and the entry on Warburg-effect diet claims.
In plain words · A metabolic enzyme whose mutant form produces a molecule that scrambles how genes are read; blocking it slows brain tumours and leukaemias.
Showing the target this term concerns: IDH1 / IDH2.
Shares Hallmarks of Cancer, VHL / HIF oxygen sensing, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.