{"entity":{"id":"deregulating-cellular-energetics","kind":"term","name":"Hallmark: reprogramming cellular metabolism","aka":[],"tldr":"Cancer cells rewire their metabolism to build biomass fast, burning glucose inefficiently and gorging on glutamine and lipids.","summary":"Reprogramming cellular metabolism is the hallmark by which cancer cells rewire their metabolism to build biomass quickly, burning glucose inefficiently and consuming large amounts of glutamine and lipids. The Warburg effect and its relatives define this hallmark, which is described in the Cancer metabolism, VHL / HIF oxygen sensing and KEAP1-NRF2 antioxidant pathways. It is exploited clinically by FDG PET for imaging, by antimetabolite chemotherapy and by inhibitors of IDH1 / IDH2, whereas broader metabolic drugs have struggled against metabolic plasticity. Readers meet this hallmark from the Hallmarks of Cancer overview, the Cancer metabolism, Glutamine addiction and lipid metabolism pathway pages, and the entry on Warburg-effect diet claims.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer","links":[{"label":"Hanahan, Hallmarks of Cancer: New Dimensions (Cancer Discovery 2022)","url":"https://doi.org/10.1158/2159-8290.CD-21-1059"}],"tags":["hallmark"],"related":[],"cancers":[],"sections":[],"technologies":["fdg-pet"],"targets":["idh"],"drugs":[],"companies":[],"institutions":[],"pathways":["cancer-metabolism","hif-vhl","keap1-nrf2"],"terms":["warburg-effect"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/deregulating-cellular-energetics/","neighbours":{"technology":[{"id":"fdg-pet","kind":"technology","name":"FDG PET","route":"/technologies/fdg-pet/"}],"target":[{"id":"idh","kind":"target","name":"IDH1 / IDH2","route":"/targets/idh/"}],"pathway":[{"id":"cancer-metabolism","kind":"pathway","name":"Cancer metabolism","route":"/pathways/cancer-metabolism/"},{"id":"glutamine-metabolism","kind":"pathway","name":"Glutamine addiction","route":"/pathways/glutamine-metabolism/"},{"id":"keap1-nrf2","kind":"pathway","name":"KEAP1-NRF2 antioxidant pathway","route":"/pathways/keap1-nrf2/"},{"id":"lipid-metabolism-cancer","kind":"pathway","name":"Lipid synthesis, uptake & cholesterol","route":"/pathways/lipid-metabolism-cancer/"},{"id":"hif-vhl","kind":"pathway","name":"VHL / HIF oxygen sensing","route":"/pathways/hif-vhl/"}],"term":[{"id":"hallmarks-of-cancer","kind":"term","name":"Hallmarks of Cancer","route":"/terms/hallmarks-of-cancer/"},{"id":"hallmarks-synthesis","kind":"term","name":"Hallmarks of cancer as a synthesis of the theories","route":"/terms/hallmarks-synthesis/"},{"id":"metabolic-theory-of-cancer","kind":"term","name":"Metabolic theory of cancer: from Warburg to oncometabolites","route":"/terms/metabolic-theory-of-cancer/"},{"id":"warburg-effect","kind":"term","name":"Warburg effect","route":"/terms/warburg-effect/"},{"id":"warburg-effect-diet-claims","kind":"term","name":"Warburg-effect diet claims ('sugar feeds cancer')","route":"/terms/warburg-effect-diet-claims/"}]}}